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Nothofagin

SKU: orb1684369

Description

Nothofagin

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number11023-94-2
MW436.41
Purity99.21%
FormulaC21H24O10
SMILESOC1=C(C(O)=CC(O)=C1C(CCC2=CC=C(O)C=C2)=O)[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O
TargetTNF,ERK,IL Receptor,Calcium Channel
SolubilityDMSO:25 mg/mL (57.29 mM)

Bioactivity

In Vivo
Oral administration of matrine at 1 mg/kg per day for 7 consecutive days significantly increase the urinary volume of both normotensive (NTR) and spontaneously hypertensive rats (SHR).
In Vitro
Pre-treatment of DNPHSA-stimulated RBL-2H3 with 10 μM Nothofagin markedly suppresse the phosphorylation of Lyn, Syk, and Akt. Nothofagin pre-treatment (0.1, 1, 10 μM) decrease the level of histamine release in RBL-2H3 and RPMCs cells. furthermore , Nothofagin suppresses IgE-mediated mast cell degranulation both in vitro and in vivo

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

TNF-α, ERK, IL Receptor, Nothofagin, ILReceptor
Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Nothofagin (orb1684369)

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Available Sizes

Select a size below

1 mg
¥ 4,420.00
5 mg
¥ 9,100.00
1 ml x 10 mM (in DMSO)
¥ 10,140.00
10 mg
¥ 12,090.00
25 mg
¥ 17,810.00
50 mg
¥ 23,270.00
100 mg
¥ 31,460.00
DispatchUsually dispatched within 3-5 working days
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