Oleic acid

SKU: orb1304743

Description

Oleic acid (Glycon Wo) is a common monounsaturated fatty acid naturally present in many animal and vegetable fats. It functions as an activator of the Na+/K+ ATPase enzyme and is widely used in biochemical research to study ion transport mechanisms in both cellular and physiological models.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	112-80-1
MW	282.46
Purity	99.91% (May vary between batches)
Formula	C₁₈H₃₄O₂
SMILES	C(C/C=C\CCCCCCCC)CCCCCC(O)=O
Target	ATPase,Endogenous Metabolite,Apoptosis
Solubility	5% DMSO+95% Saline:3 mg/mL (10.62 mM);DMSO:250 mg/mL (885.08 mM)

Bioactivity

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Target IC50	FFA1/GPR40:58.4 μM (EC50)\|GPR3:300 μM (EC50)\|W83 cells:1.55 nM\|gastric H+, K (+)-ATPase:12 μM\|Porcine Pancreatic Lipase:11.7 µg/mL (41.4µM)
In Vivo	METHODS: To detect the antitumor activity in vivo, Oleic acid (10 mg/kg) was administered by gavage to LKB1fl/flp53fl/fl endometrial tumor mouse model five days per week for four weeks. RESULTS: Oleic acid treatment for four weeks significantly inhibited tumor growth by 52.1%.Oleic acid exhibits anti-tumor activity in endometrial cancers, which is dependent on the PTEN/AKT/mTOR signaling pathway. METHODS: To study its role in ischemic injury, Oleic acid (10-30 mg/kg, 5% Tween 20 in sterile saline) was administered intraperitoneally to rodent models of middle cerebral artery occlusion (MCAO), photochromic and four-vessel occlusion (4-VO). RESULTS: Oleic acid administration reduced MCAO-induced infarct volume and functional deficits, photochromic-induced infarct volume, and 4-VO-induced hippocampal neuronal death. Read more...
In Vitro	METHODS: Human tumor cells HCG-27, AGS, MDA-MB-231, SGC7901, BGC823 and MCF-7 were treated with Oleic acid (400 μM) for 24-72 h. Cell viability was detected using MTT. RESULTS: Oleic acid stimulated cell viability in HGC-27, MDA-MB-231 cells, and inhibited cell viability in AGS, SGC7901, BGC823 and MCF-7 cells. METHODS: Renal cell carcinoma cells 786-O were treated with Oleic acid (0.05-0.2 mM/L) for 48 h. Apoptosis was detected by Flow Cytometry. RESULTS: Oleic acid retarded apoptosis of 786-O cells in a concentration-dependent manner. Read more...

Storage & Handling

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Storage	store at low temperature \| Pure form: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, Na+/K+ ATPase, Oleate, Oleic acid, Elaidoic acid, EndogenousMetabolite, Endogenous Metabolite, Glycon Wo, Inhibitor, Apoptosis, 9-cis-Octadecenoic acid, 9-Octadecenoic Acid, 9Z-Octadecenoic acid, Sodium potassium pump

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Compound Identifiers

PubChem CID

445639 ↗

Key Properties

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No computed properties available.

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Oleic acid (orb1304743)

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Purity:	>98%
CAS Number:	67254-28-8
MW:	797.026
Formula:	C₄₂H₇₈NAO₁₀P

Purity:	>98%
CAS Number:	6418-95-7
MW:	397.25406
Formula:	C₄₁H₈₀NO₈P

Purity:	99.24% (May vary between batches)
CAS Number:	303-43-5
MW:	651.1
Formula:	C₄₅H₇₈O₂

CAS Number:	8007-43-0
MW:	1175.7
Formula:	C₆₆H₁₂₆O₁₆

CAS Number:	143-18-0
MW:	320.55
Formula:	C₁₈H₃₃KO₂

Oleic acid

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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