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Onalespib

SKU: orb1300903

Description

Onalespib

Research Area

Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number912999-49-6
MW409.52
Purity99.01%
FormulaC24H31N3O3
SMILESCC(C)c1cc(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c(O)cc1O
TargetHSP
SolubilityDMSO:2.04 mg/mL (4.98 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.44 mM)

Bioactivity

Target IC50
HSP90 (AT13387):18 nM
In Vivo
AT13387 is a potent inhibitor o the proliferation and survival of many different cell lines from a wide range of different tumor types (e.g., MES-SA cell line). In a panel of 30 tumor cell lines, AT13387 effectively inhibited cell proliferation with GI50 Values in the range of 13-260 nM. AT13387 inhibite the proliferation o the non-tumorigenic human prostate epithelial cell line PNT2 with a GI50 value of 480 nM.
In Vitro
AT13387 is a potent inhibitor o the proliferation and survival of many different cell lines from a wide range of different tumor types (e.g., MES-SA cell line). In a panel of 30 tumor cell lines, AT13387 effectively inhibited cell proliferation with GI50 Values in the range of 13-260 nM. AT13387 inhibite the proliferation o the non-tumorigenic human prostate epithelial cell line PNT2 with a GI50 value of 480 nM.
Cell Research
The human cell lines including A375, 22RV1, T474, DU1 45, LNCa P, MCF-7, DA-MB-468 are seeded into 96-well plates befor the addition of AT13387 in 0.1% (v/v) DMSO. GI50 are determined using a 10-point dose response curve for three cell doubling times. After AT13387 incubation 10% (v/v), Alamar blueis added, and cells are incubated for a further 4 hours. Fluorescence is read.(Only for Reference)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

AT 13387, AT13387, AT-13387, Onalespib, Onalespib (AT13387), inhibit, HSP, HSP90, Inhibitor, Heat shock proteins

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

Romy Cools # 1, Valeria Narykina # 1 2 3, Koen Vermeulen 4, Sanket J Mishra 5, Brian S J Blagg 5 6, Marleen Derweduwe 7 8 9, Frederik De Smet 7 8 9, Aaron Ziani-Zeryouh 10, Matteo Riva 10 11, An Coosemans 10, Frederic Rousseau 2 3, Joost Schymkowitz 2 3, Guy Bormans 12 [11C]HSP990 PET as a translational tool to investigate the role of Hsp90 in tumours and support the development of Hsp90 therapeutics EJNMMI Radiopharm Chem, (2025)

Onalespib (orb1300903)

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Step 1: Enter information below

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Step 2: Enter the in vivo formulation

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,040.00
2 mg
¥ 1,300.00
1 ml x 5 mM (in DMSO)
¥ 1,690.00
5 mg
¥ 1,690.00
10 mg
¥ 2,730.00
25 mg
¥ 4,030.00
50 mg
¥ 5,460.00
100 mg
¥ 7,930.00
200 mg
¥ 10,790.00
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