Palmitic acid

SKU: orb1304861

Description

Palmitic acid

Research Area

Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	57-10-3
MW	256.42
Purity	99.17%
Formula	C₁₆H₃₂O₂
SMILES	C(CCCCCCCCCC)CCCCC(O)=O
Target	Endogenous Metabolite,HSP
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:0.26 mg/mL (1.01 mM);DMSO:100 mg/mL (389.99 mM);Ethanol:40.83 mg/mL (159.23 mM)

Bioactivity

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Target IC50	Colo-320-DM cells:0.35 µg/mL\|Caco-2 cells:0.75 µg/mL\|MCF-7 cells:0.55 µg/mL\|WRL-68 cells:1 µg/mL
In Vivo	METHODS: To investigat the effects on adverse biological behaviors in mice, Palmitic acid (0.3-30 μMol/mouse in castor oil) was administered as a Single intraperitoneal injection to C57BL/6J mice, and biological behaviors were analyzed 2-24 h later. Results: In a dose-dependent manner, Palmitic acid rapidly reduced locomotor activity in mice through a mechanism dependent on fatty acid chain length. 24 h after Palmitic acid administration, mice exhibited anxiety-like behaviors, whereas there was no impairment of locomotion, food intake, depression-like behaviors, or spatial memory. METHODS: To investigat the effects on myocardial injury, Palmitic acid (5 mM in 500 μL solution) was injected intravenously int the tail of wild-type C57BL/6 (B6) and Md2-/- (KO) mice once a day for seven days. Results: Palmitic acid induced myocardial inflammatory injury via TLR4 accessory protein MD2 and protected Md2 knockout mice from myocardial injury induced by Palmitic acid and high-fat diet. Read more...
In Vitro	METHODS: Mouse microglia BV2 were treated with Palmitic acid (25-200 nM) for 6-48 h, and cell viability was measured by MTT. Results: Palmitic acid had concentration and time-dependent inhibitory effects on microglia viability. METHODS: Monocyte-derived dendritic cells MoDC were treated with Palmitic acid ( 50 μM) for 12 h the expression of DC co-stimulatory factors was measured by Flow Cytometry. Results: Palmitic acid induce the expression of CD86 and CD83, indicating tha the activation and maturation of MoDC were induced simultaneously. Read more...
Cell Research	Cell Experiment Solubilisation Formula: 1. Dissolve 1 mg of palmitic acid in 78 μL of anhydrous ethanol to obtain a 50 mM stock solution; if a higher concentration is required, dissolve 1 mg of palmitic acid in 39 μL of anhydrous ethanol to obtain a 100 mM stock solution. 2. Prepare a 10% BSA solution using culture medium (e.g., DMEM); BSA without fatty acids is preferable, with a concentration of 100 mg/mL. 3. Fo the solvent control group, prepare ethanol and BSA control solutions a the corresponding concentration without lipids. 4. As an example of preparing 1 mL of a 0.25 mM working solution, mix 5 μL of 50 mM palmitic acid stock solution + 100 μL of 10% BSA solution + 895 μL of culture medium the final solution will contain 1% BSA the ethanol concentration should be controlled between 0.1%~0.5%. 5. Filte the working solution using a sterile filter membrane for use in cell processing. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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Inhibitor, inhibit, Palmitic acid, hexadecanoic acid, Hexadecoic acid, Heat shock proteins, EndogenousMetabolite, Endogenous Metabolite, HSP, Cetylic acid

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Compound Identifiers

PubChem CID

985 ↗

Key Properties

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No computed properties available.

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Palmitic acid (orb1304861)

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Applications:	ELISA, WB
Reactivity:	A. thaliana
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Purity:	98.0%（HPLC）
CAS Number:	57-10-3

CAS Number:	628-97-7
MW:	284.48
Formula:	C₁₈H₃₆O₂

CAS Number:	137-66-6
MW:	414.53
Formula:	C₂₂H₃₈O₇

Palmitic acid

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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