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Pamapimod

SKU: orb1300339

Description

Pamapimod

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number449811-01-2
MW406.38
Purity99.99%
FormulaC19H20F2N4O4
SMILESCn1c2nc(NC(CCO)CCO)ncc2cc(Oc2ccc(F)cc2F)c1=O
TargetAutophagy,p38 MAPK
SolubilityDMSO:45 mg/mL (110.73 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:27 mg/mL (66.44 mM)

Bioactivity

Target IC50
p38α:0.014 ± .00 μM|p38β:0.4 ± .04 μM
In Vivo
In murine collagen-induced arthritis, pamapimod reduced Clinicalal signs of inflammation and bone loss at 50 mg/kg or greater. In a rat model of hyperalgesia, pamapimod increased tolerance to pressure in a dose-dependent manner, suggesting an important role of p38 in pain associated with inflammation. Pamapimod suppresses spontaneous production of TNFα by synovial explants from RA patients. LPS- and TNFα-stimulated production of TNFα and IL-6 in rodents also was inhibited by pamapimo.
In Vitro
Pamapimod inhibited p38, but Inhibition of JNK was not detected. Pamapimod also inhibited lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF) α production by monocytes, interleukin (IL)-1β production in human whole blood, and spontaneous TNFα production by synovial explants from RA patient.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

Autophagy, anti-inflammation, inhibit, IL-1β, IL-6, Inhibitor, JNK, Pamapimod, LPS, p38 MAPK, p38MAPK, p38α, p38β, R 1503, R1503, R-1503, TNF-α, Ro4402257, Ro-4402257, Ro 4402257

Similar Products

  • Pamapimod [orb1225026]

    >98% (HPLC)

    449811-01-2

    406.4

    C19H20F2N4O4

    1 g, 100 mg, 500 mg, 5 mg, 50 mg, 10 mg, 25 mg
Quality Guarantee

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Key Properties

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Pamapimod (orb1300339)

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Available Sizes

Select a size below

1 mg
¥ 1,300.00
5 mg
¥ 2,210.00
1 ml x 10 mM (in DMSO)
¥ 2,340.00
10 mg
¥ 3,120.00
25 mg
¥ 5,720.00
50 mg
¥ 8,840.00
100 mg
¥ 12,220.00
500 mg
¥ 23,790.00
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