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PD-1/PD-L1-IN-10

SKU: orb1297978

Description

PD-1/PD-L1-IN-10

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

Key Properties

CAS Number2487550-41-2
MW581.62
Purity97.81%
FormulaC33H31N3O7
SMILESCC(O)[C@H](NCc1cc(c(OCc2cccc(c2C)-c2ccccc2)cc1OCc1cccc(c1)C#N)[N+]([O-])=O)C(O)=O
TargetPD-1/PD-L1,Apoptosis
SolubilityDMSO:100 mg/mL (171.93 mM);10% DMSO+90% Saline:3.3 mg/mL (5.67 mM)

Bioactivity

Target IC50
PD-1/PD-L1:2.7 nM
In Vivo
PD-1/PD-L1-IN-10 (compound B2, 5 mg/kg, intragastric gavage) exhibits potent in vivo anticancer efficacy by effectively blocking tumor cell proliferation and inducing apoptosis in LLC tumor tissues in an LLC-bearing allograft mouse model
In Vitro
PD-1/PD-L1-IN-10 (compound B2) effectively enhances interferon-gamma secretion in vitro in a dose-dependent manner, starting at 1 nM, without compromisin the viability of Lewis lung carcinoma (LLC) cells or lymph node T-cell. It significantly stabilizes PD-L1 protein levels in LLC cells withi the 0-100 nM range, showing a dose-dependent effect on PD-L1 stability at 58 °C, suggesting penetration and Direct interaction with PD-L.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

carcinoma, Apoptosis, PD 1/PD L1 IN 10, PD-1/PD-L1, PD1/PDL1, PD1/PDL1IN10, PD-1/PD-L-1-IN-10, PD-1/PD-L1-IN-10, PD1, PD-1, lung, LLC, inhibit, Lewis, Inhibitor, IFN-γ, tumor, PDL1, PD-L1, T-lymphocyte
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Key Properties

No computed properties available.

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Protocol Information

PD-1/PD-L1-IN-10 (orb1297978)

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Step 1: Enter information below

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,170.00
5 mg
¥ 1,820.00
1 ml x 10 mM (in DMSO)
¥ 2,080.00
10 mg
¥ 2,860.00
25 mg
¥ 4,940.00
50 mg
¥ 8,320.00
100 mg
¥ 11,700.00
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