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Pentoxyverine

SKU: orb1704841

Description

Pentoxyverine (Carbetapentan) is an orally active antitussive agent that functions as a muscarinic M1 receptor antagonist and a σ1 receptor agonist, leading to alveolar relaxation. It is utilized in respiratory research to investigate cough reflex mechanisms and receptor pharmacology in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number77-23-6
MW333.47
Purity97.11%
FormulaC20H31NO3
SMILESO=C(OCCOCCN(CC)CC)C1(C=2C=CC=CC2)CCCC1
TargetSigma receptor,AChR
SolubilityDMSO:200 mg/mL (599.75 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.99 mM)

Bioactivity

Target IC50
σ1 receptor:75 nM (Ki)
In Vivo
Pentoxyverine (30-60 mg/kg, i.p.) exhibits antinociceptive effects in mice in thermal and inflammatory pain models. Pentoxyverine's effects are σ₁ receptor-dependent, as shown by partial reversal with σ₁ antagonist BD1047.
In Vitro
Pentoxyverine binds human σ₁ receptors with moderate affinity (Ki ~100-300 nM) and activates typical σ₁-mediated cellular responses such as calcium flux.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Pentoxyverine, Carbetapentane

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Quality Guarantee

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Key Properties

No computed properties available.

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Pentoxyverine (orb1704841)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
¥ 910.00
10 mg
¥ 1,040.00
25 mg
¥ 1,430.00
50 mg
¥ 1,690.00
100 mg
¥ 2,210.00
200 mg
¥ 2,990.00
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