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PF-06651600

SKU: orb1225905

Description

PF-06651600 is a novel potent, selective JAK3 inhibitor with IC50 of 0.346 nM, displays >1,000-fold selectivity over JAK1 and JAK2; inhibits Th1 and Th17 cell differentiation and function, reduces disease pathology in rat adjuvant-induced arthritis as well as in mouse experimental autoimmune encephalomyelitis models; selectively targets γc cytokine pathways while preserving JAK1-dependent anti-inflammatory signaling such as the IL-10 suppressive functions following LPS treatment in macrophages and the suppression of TNFα and IL-1β production in IL-27-primed macrophages.Rheumatoid ArthritisPhase 2 Clinical

Images & Validation

Key Properties

CAS Number1792180-81-4
MW285.4
Purity>98% (HPLC)
FormulaC15H19N5O
TargetJAK

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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PF-06651600 (orb1225905)

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Available Sizes

Select a size below

2 mg
¥ 1,040.00
5 mg
¥ 1,430.00
10 mg
¥ 2,340.00
25 mg
¥ 4,160.00
50 mg
¥ 6,240.00
100 mg
¥ 9,100.00
200 mg
¥ 12,740.00
500 mg
¥ 18,980.00