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PF-06882961 Tris

SKU: orb1298560

Description

PF-06882961 Tris is an orally administered small molecule agonist of the glucagon-like peptide-1 receptor (GLP-1R). This research compound is utilized in preclinical studies to investigate metabolic diseases, including diabetes and obesity, through both in vitro receptor assays and in vivo pharmacological models.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2230198-03-3
MW676.7
Purity98.74%
FormulaC35H41FN6O7
SMILESC1CO[C@@H]1CN2C3=C(C=CC(=C3)C(=O)O)N=C2CN4CCC(CC4)C5=NC(=CC=C5)OCC6=C(C=C(C=C6)C#N)F.C(C(CO)(CO)N)O
TargetGlucagon Receptor
SolubilityDMSO:45 mg/mL (66.5 mM)

Bioactivity

In Vivo
PF-06882961 Tris shows mild to moderate damage to the heart, moderate to severe effects on the thymus gland (which helps with managing infection), mild to moderate stomach ulcers at the highest dose level given in the rat.
In Vitro
Biological in-vitro testing revealed favorable ADME and pharmacological profiles for the best PF-06882961 Tris.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GlucagonReceptor, Glucagon Receptor, GLP-1, PF06882961 Tris, PF-06882961 Tris, PF 06882961 Tris, UNII-2HJV78O0SS

Similar Products

  • PF-06882961 Tris [orb1218404]

    >98% (HPLC)

    2230198-03-3

    676.7

    C35H41FN6O7

    25 mg, 50 mg, 10 mg, 1 g, 500 mg, 5 mg, 100 mg
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Key Properties

No computed properties available.

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Protocol Information

PF-06882961 Tris (orb1298560)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 2,340.00
5 mg
¥ 4,550.00
10 mg
¥ 6,500.00
25 mg
¥ 10,270.00
50 mg
¥ 14,170.00
100 mg
¥ 18,980.00
500 mg
¥ 37,310.00
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