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Piclidenoson

SKU: orb1220529

Description

Piclidenoson a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM) induces robust anti-inflammatory effect in psoriasis patients.

Images & Validation

Key Properties

CAS Number152918-18-8
MW510.29
Purity>98% (HPLC)
FormulaC18H19IN6O4
SMILESCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)ncnc12
TargetAdenosine Receptor
SolubilityDMSO:45 mg/mL (88.19 mM)

Bioactivity

In Vivo
Animal model: B10CBAF1 male mice aged 3 months (average 30 g). Dosage: 105 μg/kg. Administration: Intraperitoneal injection, 0.5 h after irradiation. Result: Resulted in statistically significant increases of the mean survival time in comparison with the control irradiated mice.
In Vitro
Cell Proliferation Assay Cell line: OVCAR-3 cells, Caov-4 cells. Concentration: 0.0001-100 μM Incubation time: 48 hours. Result: Resulted in a dose-dependent reduction in the cell viability. Apoptosis Analysis Cell line: OVCAR-3 cells, Caov-4 cells. Concentration: 0.1 μM, 1 μM, 10 μM, 50 μM, 100 μM Incubation time: 48 hours. Result: Significant increased in the percentage of apoptosis in a concentration-dependent manner. Western blot analysis. Cell line: OVCAR-3 cells, Caov-4 cells. Concentration: 1 μM, 10 μM, 100 μM. Incubation time: 48 hours. Result: Decreased the expression of Bcl-2 was noticeably and increased the expression of Bax protein.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

IB-MECA | CF-101

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  • Piclidenoson [orb1299997]

    100.00% (May vary between batches)

    152918-18-8

    510.29

    C18H19IN6O4

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 200 mg, 1 mg, 100 mg, 500 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

Available Sizes

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2 mg
$ 110.00
5 mg
$ 170.00
10 mg
$ 260.00
25 mg
$ 520.00
50 mg
$ 830.00
100 mg
$ 1,270.00
200 mg
$ 1,680.00
500 mg
$ 2,530.00