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Piclidenoson

SKU: orb1299997

Description

Piclidenoson

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number152918-18-8
MW510.29
Purity100.00% (May vary between batches)
FormulaC18H19IN6O4
SMILESCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)ncnc12
TargetAdenosine Receptor|||Apoptosis
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.92 mM);DMSO:60 mg/mL (117.58 mM)

Bioactivity

In Vitro
Piclidenoson inhibited the proliferation of HaCat cells through deregulation of the NF-κB signaling pathway, leading to a decrease in interleukin-17 and interleukin-23 expression levels.
Cell Research
[3H]-Thymidine incorporation assay was used to evaluate cell growth. HaCat cells (2500 cells/well) were incubated with piclidenoson 10 nM and MRS 1523 (50 nM) in 96-well plate for 48 hours. For the last 24 hours of incubation, each well was pulsed with 1 mCi [3H]-thymidine. Cells were harvested, and the [3H]-thymidine uptake was determined in an LKB liquid scintillation counter (LKB, Piscataway, NJ, USA). These experiments were repeated at least 4 times.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CF 101, CF101, CF-101, colon, breast, diseases, COVID-19, AdenosineReceptor, Adenosine Receptor, A3, Apoptosis, autoimmune, antiproliferative, inflammatory, inhibit, leukemia, melanoma, IB-MECA, Inhibitor, Piclidenoson, P1 receptor, prostate

Similar Products

  • Piclidenoson [orb1220529]

    >98% (HPLC)

    152918-18-8

    510.29

    C18H19IN6O4

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 90.00
2 mg
$ 100.00
5 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 150.00
10 mg
$ 200.00
25 mg
$ 370.00
50 mg
$ 570.00
100 mg
$ 870.00
200 mg
$ 1,130.00
500 mg
$ 1,750.00
DispatchUsually dispatched within 5-10 working days
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