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PIM447

SKU: orb1708852

Description

PIM447 (LGH447) is an orally bioavailable, selective pan-PIM kinase inhibitor with demonstrated antitumor and bone-protective activity. It induces apoptosis and inhibits proliferation in hepatocellular carcinoma and multiple myeloma cell lines, supporting its use in oncology research for both in vitro and in vivo studies.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Images & Validation

Key Properties

CAS Number1210608-43-7
MW440.46
Purity98.97%
FormulaC24H23F3N4O
SMILESFC1=C(N=C(C(NC=2C(=CC=NC2)[C@@H]3C[C@H](C)C[C@H](N)C3)=O)C=C1)C4=C(F)C=CC=C4F
TargetApoptosis,Pim
SolubilityDMSO:80 mg/mL (181.63 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.35 mM)

Bioactivity

Target IC50
Pim1:6 pM (Ki)|Pim2:18 pM (Ki)|Pim3:9 pM (Ki)
In Vivo
PIM447 significantly reduced tumor load and prevented tumor-associated bone loss in a disseminated mouse model of human myeloma.
In Vitro
HuH6 and COA67 cells were treated with PIM447 (0-20 μM, 72h), and the activity of PIM447 was significantly reduced with LD50 of 13 μM and 10 μM, respectively. Treatment with PIM447 (7.5 μM, 8h) resulted in increased apoptosis of HuH6 and COA67 cells. PIM447 (5 μM, 48h) reduced cancer cell dryness in HuH6 and COA67 cells.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

LGH 447, LGH447, LGH-447, PIM 447, PIM447, PIM-447

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Key Properties

No computed properties available.

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PIM447 (orb1708852)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 2,080.00
5 mg
¥ 4,160.00
1 ml x 10 mM (in DMSO)
¥ 4,420.00
10 mg
¥ 6,500.00
25 mg
¥ 10,530.00
50 mg
¥ 13,390.00
DispatchUsually dispatched within 5-10 working days
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