Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

PK-11007

SKU: orb1225142

Description

A 2-sulfonylpyrimidine compound that is a mild thiol alkylator with anticancer activity toward p53-compromised cells; stabilizes p53 in vitro via selective alkylation of two surface-exposed cysteines without compromising p53 DNA binding activity; also induces cell death independent of p53, but with highly elevated levels of ROS and induction of ER stress.

Images & Validation

−
PK-11007

Key Properties

−
CAS Number38275-34-2
MW236.63
Purity>98% (HPLC)
FormulaC6H5ClN2O4S
SMILESO=C(C1=NC(S(=O)(C)=O)=NC=C1Cl)O
TargetMDM2-p53
SolubilityDMSO : 100 mg/mL 422.60 mM

Bioactivity

−
In Vitro
PK11000 (0-120 μM, 24 h) mildly inhibits mutant p53 cancer cells. PK11000 (0-50 μM, 5 d) shows anti-proliferation effects of breast cell lines. Cell Viability Assay Cell line: WI-38, HUH-6, NUGC-4, SJSA-1, HUH-7, NUGC-3, SW480 and MKN1 cells. Concentration: 0-120 μM. Incubation time: 24 hours. Result: Inhibited NUGC-3 cells mildly. Cell Proliferation Assay Cell line: UACC812, BT474, ZR-75-1, SUM 159, MDA-MD-468, MDA-MD-453, T47D, Hs578T(i8), MCF7, HCC1937, JimT1, BT20, HCC1143, BT549, SKBR3, MCF12A, MCF10A cells. Concentration: 0-50 μM. Incubation time: 5 days. Result: Inhibited breast cell lines with IC50 values ranging from 2.5 to >50 μM.

Storage & Handling

−
StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

−
PK11007

Similar Products

−
  • PK11007

    PK11007 [orb1299578]

    ≥98% (May vary between batches)

    874146-69-7

    427.86

    C15H11ClFN5O3S2

    1 ml x 10 mM (in DMSO), 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Quick Database Links

Gene Symbol
MDM2-p53

Protocol Information

Find More Protocols

Available Sizes

Select a size below

200 mg
Enquire
500 mg
Enquire
1 g
Enquire
5 mg
$ 70.00
10 mg
$ 110.00
25 mg
$ 190.00
50 mg
$ 290.00
100 mg
$ 470.00
Bulk Enquiry
Need technical support? Find your Distributor Return and Tax Policy

Email

[email protected]

UK Office

+44 (0)1223 859353

US Office

+1 (415) 906-5211

CN Office

+86 (27)-87663101

Distributors

biorbyt.com/distributor