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PK11007

SKU: orb1299578

Description

PK11007 is a small molecule inhibitor targeting the p53 protein for research use. It is applied in oncology studies to investigate p53-dependent pathways and cellular responses in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number874146-69-7
MW427.86
Purity≥98% (May vary between batches)
FormulaC15H11ClFN5O3S2
SMILESCc1nnc(NC(=O)c2nc(ncc2Cl)S(=O)(=O)Cc2ccc(F)cc2)s1
TargetMdm2,MDM-2/p53,p53,Reactive Oxygen Species,ROS
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.35 mM);DMSO:100 mg/mL (233.72 mM)

Bioactivity

In Vivo
Targeting mutant p53 with PK11007 is a potential approach for treating p53-mutated breast cancer, including the subgroup with TN disease.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, MDM-2/p53, p53, inhibit, PK11007, PK-11007, PK 11007, ReactiveOxygenSpecies, Reactive Oxygen Species

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 120.00
5 mg
$ 120.00
10 mg
$ 150.00
25 mg
$ 240.00
50 mg
$ 340.00
100 mg
$ 480.00
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