Pomaglumetad methionil hydrochloride

SKU: orb1688066

Description

Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active prodrug metabolized to LY404039, a selective mGlu2/3 receptor agonist. It has been investigated in preclinical and clinical research for its potential application in schizophrenia.

Research Area

Neuroscience

Images & Validation

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Key Properties

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CAS Number	635318-26-2
MW	402.87
Purity	99.01% (May vary between batches)
Formula	C₁₂H₁₉ClN₂O₇S₂
SMILES	Cl.[H][C@@]12[C@@H](C(O)=O)[C@]1([H])S(=O)(=O)C[C@@]2(NC(=O)[C@@H](N)CCSC)C(O)=O
Target	GluR
Solubility	DMSO:22.5 mg/mL (55.85 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.96 mM)

Bioactivity

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In Vivo	Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) induces dose-dependent increases in the levels of dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) . Read more...
In Vitro	Pomaglumetad methionil (LY2140023) is a high-affinity substrate for peptide transporter 1 (PEPT1) with a Km of approximately 30 µM and demonstrates activity against [14C]Gly-Sar, exhibiting an IC50 of 0.018 mM. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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mGluR2, mGluR3, LY2140023 hydrochloride, LY2140023 Hydrochloride, LY-2140023 Hydrochloride, LY 2140023 Hydrochloride, Pomaglumetad methionil Hydrochloride

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Compound Identifiers

PubChem CID

66903228 ↗

Key Properties

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No computed properties available.

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