PPARδ agonist 11

SKU: orb2665100

Description

Compound 11 is a potent and selective PPARδ agonist (EC50 = 20 nM) with demonstrated anti-inflammatory effects in vitro, suppressing NO, TNFα, and IL-6 via NF-κB in LPS-stimulated macrophages. It shows high metabolic stability, excellent oral bioavailability (~100%), and effectively reduces carrageenan-induced foot edema in vivo, making it a valuable tool for metabolic and inflammatory disease research.

Research Area

Metabolism Research, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	2982696-04-6
MW	440.46
Formula	C₁₉H₁₅F₃N₂O₃S₂
SMILES	O=C(O)COC1=CC=C(SCC2=NN=C(S2)C=3C=CC(=CC3)C(F)(F)F)C=C1C
Target	PPAR

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

138454901 ↗

Key Properties

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No computed properties available.

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