Pranlukast

SKU: orb1310378

Description

Pranlukast

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	103177-37-3
MW	481.5
Purity	99.85%
Formula	C₂₇H₂₃N₅O₄
SMILES	N(C(=O)C1=CC=C(OCCCCC2=CC=CC=C2)C=C1)C3=C4C(C(=O)C=C(O4)C=5NN=NN5)=CC=C3
Target	Endogenous Metabolite,IL Receptor,LTR,TNF,Leukotriene Receptor,NF-κB
Solubility	DMSO:45 mg/mL (93.46 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.15 mM)

Bioactivity

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Target IC50	LTE4:0.63 nM (Ki)\|LTC4:5640 nM (Ki)\|LTD4:0.99 nM (Ki)
In Vivo	In sensitized guinea pig tracheas, 5 mM of either Pranlukast or Zafirlukast significantly inhibited ovalbumin-induced secretion by 70% and 65%, respectively These compounds also markedly inhibited 35SO4 release triggered by 10 mM LTD4 in a concentration dependent manner, with Pranlukast showing a peak Inhibition of 83% and Zafirlukast 78% at 10 mM, having IC50 Values of 0.3 mM and 0.6 mM, respectively Pranlukast suppresse the activation of NF-κB in 1.3% DMSO-differentiated U-937 and Jurkat cells, with Inhibition rates of 40% and 30%; it also demonstrated a dose-dependent Inhibition of NF-κB activation in combination with MK-571. Pranlukast and MK-571 diminished LPS-induced IL-6 production in PBMCs by approximately 65% and 15%. Additionally, Pranlukast inhibite the activation of NF-κB induced by phorbol 12-myristate 13-acetate and significantly reduced LPS-induced MUC2 mRNA expression in NCI-H292 cells, as determined by reverse transcription-polymerase chain reaction. Pranlukast also suppresse the expression o the MUC2 gene in LPS-stimulated HM3-MUC2 cells. Read more...
In Vitro	Pranlukast significantly reduce the volume of injury in the cortical and hippocampal CA1 regions o the ischemic hemisphere in mice and increases neuronal density. Additionally, Pranlukast markedly thin the scar All in the ischemic hemisphere of mice. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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CysLTR, Mucin-2, inhibit, Inhibitor, NFκB, NF-κB, ONO 1078, ONO1078, ONO-1078, NFkB, NF-kB, LeukotrieneReceptor, Leukotriene Receptor, IL Receptor, ILReceptor, IL-5, Eosinophil cationic protein, TNF-α, Pranlukast

Quality Guarantee

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Compound Identifiers

PubChem CID

4887 ↗

Key Properties

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No computed properties available.

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Pranlukast (orb1310378)

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CAS Number:	158102-93-3
MW:	616.58
Formula:	C₂₆H₂₁F₅N₂O₆S₂

Purity:	99.28%
CAS Number:	150821-03-7
MW:	490.52
Formula:	C₂₇H₂₃N₅O₄ 0.5H₂O

Purity:	>98%(HPLC)
CAS Number:	103177-37-3
MW:	481.5
Formula:	C₂₇H₂₃N₅O₄

Pranlukast

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Pranlukast (orb1310378)

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