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Protosappanin A

SKU: orb1297669

Description

Protosappanin A

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Neuroscience, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number102036-28-2
MW272.25
Purity100.00%
FormulaC15H12O5
SMILESOc1ccc-2c(OCC(=O)Cc3cc(O)c(O)cc-23)c1
TargetNADPH-oxidase,TNF,ROS,HIV Protease,JAK,NO Synthase,NF-κB,IL Receptor,IκB/IKK,STAT,COX,Interleukin,TLR
SolubilityDMSO:225 mg/mL (826.45 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (18.37 mM)

Bioactivity

Target IC50
HIV-1 (IN):12.6 uM
In Vitro
Protosappanin A (PsA) and Protosappanin B (PsB) were identified from Sappan Lignum extracts. They showed activity against both S. aureus and MRSA with mice or IC50 at 64 (PsA) and 128 (PsB) mg/L alone. When they were used in combination with antibiotics, they showe the best synergy with amikacin and gentamicin with IC50 (mg/L) of amikacin reduced more significantly from 32 to four (with PsA) and eight (with PsB), an the fractional inhibitory concentration index (FICI) ranged between 0.078 and 0.500 (FICI50 = 0.375). Moreover the resistance of MRSA towards amikacin and gentamicin could be reversed b the Clinical and Laboratory S andards Institute criteria the combined bactericidal mode could as well be synergy. PsA and PsB showed very low cytotoxicity in comparison with their promising activity against MRS.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

NO Synthase, NO, NF-κB, NADPHoxidase, NADPH-oxidase, NFkB, NFκB, NF-kB, inhibit, NOSynthase, IL Receptor, ILReceptor, IκB, JAK, Janus kinase, IFN-γ, Inhibitor, HIV-1, HIV-1 IN, HIV Protease, HIVProtease, IkB, IKK, IkB/IKK, TLR, ROS, PTA, Protosappanin A, TNF-α, STAT

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Key Properties

No computed properties available.

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Protosappanin A (orb1297669)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,690.00
1 ml x 10 mM (in DMSO)
¥ 3,250.00
5 mg
¥ 3,510.00
10 mg
¥ 5,460.00
25 mg
¥ 8,580.00
50 mg
¥ 11,830.00
100 mg
¥ 15,730.00
DispatchUsually dispatched within 3-5 working days
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