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Quetiapine

SKU: orb1310882

Description

Quetiapine (ICI204636) is an atypical antipsychotic used in schizophrenia and bipolar I disorder research. Its mechanism involves antagonism of dopamine (D1, D2), serotonin (5-HT1A, 5-HT2), adrenergic (α1, α2), and histamine H1 receptors, making it a valuable tool for in vitro and in vivo neuropharmacology studies.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number111974-69-7
MW383.51
Purity>99.99% (May vary between batches)
FormulaC21H25N3O2S
SMILESOCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12
TargetDopamine Receptor,AChR,Histamine Receptor,Adrenergic Receptor,5-HT Receptor
SolubilityH2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.21 mM);DMSO:120 mg/mL (312.9 mM)

Bioactivity

Target IC50
5-HT2C receptor:5.55 (pKi)|D2 Receptor:6.33 (pIC50)|D2 Receptor:7.25 (pKi)|5-HT1A receptor:5.74 (pKi)|5-HT1A receptor:4.77 (pEC50)|5-HT2A receptor:7.54 (pKi)

Storage & Handling

StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

DopamineReceptor, Dopamine Receptor, Dopamine, Antidepressant, anxiolytic, 5-HT2C, 5-HT Receptor, 5HT Receptor, 5-HT1A, 5-HT2A, Adrenergic Receptor, AdrenergicReceptor, 5-hydroxytryptamine Receptor, 5HTReceptor, 5-HT, H1 receptor, ICI204636, ICI-204636, ICI 204636, Inhibitor, Histamine Receptor, HistamineReceptor, inhibit, mAChR, Serotonin Receptor, Quetiapin, Quetiapine

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Key Properties

No computed properties available.

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Quetiapine (orb1310882)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
¥ 1,170.00
10 mg
¥ 1,170.00
50 mg
¥ 1,690.00
100 mg
¥ 2,080.00
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