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(R)-Lisofylline

SKU: orb1306234

Description

(R)-Lisofylline

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number100324-81-0
MW280.32
Purity99.85%
FormulaC13H20N4O3
SMILESC[C@@H](O)CCCCn1c(=O)n(C)c2ncn(C)c2c1=O
TargetSTAT
SolubilityDMSO:45 mg/mL (160.53 mM)

Bioactivity

In Vivo
In NOD mice, (R)-Lisofylline prevents β cell dysfunction by Inhibition of STAT4 phosphorylation and ameliorates Experimental allergic encephalomyelitis. (R)-Lisofylline reduce the impairment of Insulin secretion induced by IL-1β in cultured rat islet cells, suppresses IFN-γ production the onset of diabetes, and macrophage infiltration into islets. (R)-Lisofylline improves Insulin response and lowers glucose levels in Streptozotocin-treated rats afte the oral glucose tolerance test. In rats given IL-1 intratracheally (R)-Lisofylline pretreatment reduces lung leak but does not decrease neutrophil accumulation in lungs. (R)-Lisofylline improves survival in mice injected with a lethal dose of LPS and ameliorates sepsis-induced lung injury in minipig.
In Vitro
(R)-Lisofylline inhibits IL-12-induced T cell proliferation and Th1 differentiation without affecting IL-12 secretio.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

diabetes, acid, acyltransferase, (R)Lisofylline, (R)-Lisofylline, (R)-Lisophylline, (R) Lisofylline, anti-inflammatory, IFN-γ, IL-12, inhibit, immunomodulator, Inhibitor, Lisofylline, Lisophylline, LPS, lysophosphatidic, metabolite, Pentoxifylline, STAT, STAT4
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Key Properties

No computed properties available.

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(R)-Lisofylline (orb1306234)

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1 mg
¥ 1,950.00
5 mg
¥ 7,020.00