Resatorvid

SKU: orb1296150

Description

Resatorvid

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	243984-11-4
MW	361.82
Purity	99.90%
Formula	C₁₅H₁₇ClFNO₄S
SMILES	CCOC(=O)C1=CCCC[C@H]1S(=O)(=O)Nc1ccc(F)cc1Cl
Target	Interleukin,TLR,TNF,Autophagy
Solubility	H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (13.82 mM);DMSO:255 mg/mL (704.77 mM)

Bioactivity

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Target IC50	IL-6:1.3 nM\|NO:1.8 nM\|TNF R:1.9 nM
In Vivo	METHODS: To tes the effects on cancer-comorbid depression (BCCD), Resatorvid (3 mg/kg) was administered intraperitoneally to BAL-/- mice in the BCCD model once daily for three weeks. Results: Resatorvid attenuate the symptoms of BCCD mice in vivo Resatorvid inactivated inflammatory factors and TLR4/NF-κB/NLRP3 signaling pathway in vivo METHODS: To investigat the effects on temporo andibular joint osteoarthritis (TMJOA), Resatorvid (10 mg/kg) was injected intraperitoneally twice weekly for four weeks into a CFA-induced TMJOA model in C57B-/- mice. Results: Prophylactic treatment with Resatorvid attenuated TMJOA pathology by inhibiting chondrocyte focal prolapse and degeneration, and ROS-induced macrophage inflammation via TLR4/MyD88/NF-κB/NLRP3. Read more...
In Vitro	METHODS: Breast cancer cell lines MCF7, SKBR3, MDA-MB-231 and BT-474 were treated with Resatorvid (10-150 µM) for 48 h. Cell viability was measured using MTT Assay. Results: Resatorvid dose-dependently inhibite the viability of breast cancer cell lines. METHODS: Macrophage RAW264.7 was treated with Resatorvid (1-100 nM) and LPS (5 ng/mL), IFN-γ (1 U/mL) for 4 h. Gene expression levels were measured by RT-qPCR. Results: Resatorvid inhibited LPS and IFN-γ induced mRNA expression of IL-6 and TNF-α in RAW264. Cells. Read more...
Cell Research	Cell Line: RAW264. Cells. concentration 1 nM, 10 nM, 100 nM. Incubation Time: 4 hours
Animal Research	Animal Model: 30 ApoE knockout and 30 wild-type mice on a C57BL/6 background (f Male, 10 weeks old). Dosage: 0.3 mg/kg. Administration: i.p.; twice a week; for 4 weeks Read more...

Storage & Handling

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Storage	keep away from direct sunlight,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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TLR, TLR4, TNF Receptor, TNF-R, TNFR, TAK242, TAK-242, TAK 242, Resatorvid, Toll-like Receptor (TLR), Tumor Necrosis Factor Receptor, TRIF, Interleukin Related, Interleukin, Inhibitor, inhibit, MyD88, inflammatory, IL-6, Autophagy, CLI-095, CLI095, CLI 095, diseases

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Compound Identifiers

PubChem CID

11703255 ↗

Key Properties

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No computed properties available.

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Resatorvid (orb1296150)

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Purity:	99.86%
CAS Number:	243984-10-3
MW:	361.82
Formula:	C₁₅H₁₇ClFNO₄S

Purity:	>98% (HPLC)
CAS Number:	243984-11-4
MW:	361.8
Formula:	C₁₅H₁₇ClFNO₄S

Resatorvid

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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