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Ritonavir

SKU: orb1308324

Description

Ritonavir (ABT-538) is a peptidomimetic inhibitor of HIV-1 and HIV-2 proteases. While its own antiviral activity is limited by serum protein binding, it is widely used in research, both in vitro and in vivo, as a potent cytochrome P450 inhibitor to pharmacokinetically boost other protease inhibitors.

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number155213-67-5
MW720.94
Purity>99.99% (May vary between batches)
FormulaC37H48N6O5S2
SMILESCC(C)[C@H](NC(=O)N(C)CC1=CSC(=N1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)OCC1=CN=CS1)CC1=CC=CC=C1
TargetHIV Protease,Apoptosis,SARS-CoV
SolubilityEthanol:7.21 mg/mL (10 mM);DMSO:242.5 mg/mL (336.37 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (3.47 mM)

Bioactivity

In Vivo
Ritonavir is a potent inhibitor of CYP3A-mediated biotransformation (terfenadine hydroxylation, IC50 of 0.14 mM; 17alpha-ethynylestradiol 2-hydroxylation, IC50 of 2 mM; nifedipine oxidation, IC50 of 0.07 mM).Ritonavir is a a potent inhibitor of CYP3A4-mediated testicular 6β-hydroxylation (Ki: 19 nM), and also inhibited hydroxylation by toluenesulfonylurea (IC50: 4.2 μM).Ritonavir also inhibited CYP2D6 (IC50: 2.5 mM) and CYP2C9/10 (IC50: 8.0 mM)-mediated responses.Ritonavir Ritonavir increased the cellular activity of uninfected human PBMC cultures.Ritonavir inhibited p-glycoprotein-mediated saquinavir solubilization (IC50: 0.2 μM), suggesting that Ritonavir has a high affinity for p-glycoprotein.Ritonavir significantly inhibited the metabolism of human hepatic microsomes ABT-378 (Ki: 13 nM). Ritonavir binding to ABT-378 ( in 3:1 and 29:1 ratios) was able to inhibit CYP3A (IC50: 1.1 and 4.6 μM). In cultures of uninfected human PBMCs, Ritonavir significantly reduced the susceptibility of PBMCs to apoptosis (associated with low levels of caspase-1 expression), decreased caspase-3 activity, and reduced membrane-bound protein staining. Ritonavir inhibited the induction of tumor necrosis factor produced by PBMCs and monocytes at nontoxic concentrations in a time- and dose-dependent manner.

Storage & Handling

Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ABT538, ABT-538, ABT 538, Abbott 84538, A 84538, A84538, A-84538, Apoptosis, HIVProtease, HIV Protease, HIV, Human immunodeficiency virus, Inhibitor, inhibit, Ritonavir, RTV, SARS-CoV, SARSCoV, SARS coronavirus

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

Ritonavir (orb1308324)

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20 mg
¥ 2,080.00
100 mg
¥ 3,770.00
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