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RORγt inhibitor 4

SKU: orb2945049

Description

Compound 9a is a potent, orally bioavailable, and brain-penetrant RORγt inverse agonist. It demonstrates efficacy in Th17-driven disease models, including the amelioration of clinical symptoms in experimental autoimmune encephalomyelitis (EAE) in vivo.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1426803-07-7
MW518.333
FormulaC22H16Cl2F3NO4S
SMILESO=C(NC=1C=C(Cl)C(=C(Cl)C1)C=2C=CC=CC2OC(F)(F)F)CC3=CC=C(C=C3)S(=O)(=O)C
TargetROR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information