RORγt inverse agonist 13

SKU: orb1297973

Description

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	2170477-75-3
MW	513.29
Purity	99.04%
Formula	C₂₃H₁₇Cl₂F₃N₂O₄
SMILES	OC(=O)Cc1ccc(CNC(=O)Nc2cc(Cl)c(c(Cl)c2)-c2ccccc2OC(F)(F)F)cc1
Target	ROR
Solubility	10% DMSO+90% Corn Oil:1 mg/mL (1.95 mM);DMSO:10 mg/mL (19.48 mM)

Bioactivity

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Target IC50	RORγ:63.8 nM
In Vivo	RORγt inverse agonist 13 (Compound 3i, 25 mg/kg, orally, twice daily) demonstrates an excellent in vivo PK profile and good efficacy in an IMQ-induced psoriasis mouse model. Read more...
In Vitro	RORγt inverse agonist 13 (Compound 3i) demonstrates 76% inhibition at 0.3 μM in the Th17 cell differentiation assay.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, Inhibitor, ROR, RORγt inverse agonist13, RORγt inverse agonist-13, RORγt, RORγt inverse agonist 13, RORgammat inverse agonist 13, RORrt inverse agonist 13, RAR-related orphan receptor

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Compound Identifiers

PubChem CID

138583953 ↗

Key Properties

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No computed properties available.

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