Rosmarinic acid

SKU: orb1305049

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Description

Rosmarinic acid, a naturally occurring polyphenol, exhibits potent antioxidant, anti-inflammatory, and antibacterial properties. It serves as a research tool for studying neurodegenerative pathways, demonstrating inhibitory activity against MAO-A, MAO-B, and COMT enzymes in vitro with IC50 values of 50.1, 184.6, and 26.7 μM, respectively.

Research Area

Cell Biology, Neuroscience

Images & Validation

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Key Properties

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CAS Number	20283-92-5
MW	360.32
Purity	>98%
Formula	C₁₈H₁₆O₈
SMILES	C([C@@H](OC(/C=C/C1=CC(O)=C(O)C=C1)=O)C(O)=O)C2=CC(O)=C(O)C=C2
Target	GPCR
Solubility	Soluble in DMSO (up to 15 mg/ml with warming) or in Water (up to 30 mg/ml).

Bioactivity

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Target IC50	IKKβ:12 μM
In Vivo	Rosmarinic acid (RA), a prevalent phenolic ester found extensively in the Labiatae family of herbs such as Rosmarinus officinalis, Salvia miltiorrhiza, and Prunella vulgaris, effectively mitigates colonic inflammation in mice induced with dextran sulphate sodium (DSS) through the dual inhibition of NF-κB and STAT3 pathways. Administering Rosmarinic acid (30, 60 mg/kg, p.o.) significantly reduces cytokine production in the DSS-induced colitis model. Read more...
In Vitro	Rosmarinic acid (RA) exhibits a multifunctional profile characterized by antioxidant effects, and monoamine oxidases (MAO-A and MAO-B) and catechol-O-methyl transferase (COMT) inhibition in vitro. Rosmarinic acid exhibits antioxidant effects against hydroxyl (HO(•)) and nitric oxide (NO) radicals (IC50 of 29.4 and 140 μM, respectively), and inhibition of lipid peroxidation (IC50 of 19.6 μM). Rosmarinic acid (RA) exerts a significant cytoprotective effect by scavenging intracellular ROS induced by UVB. In Water2-treated cells, 2.5 μM Rosmarinic acid scavenges 60% of intracellular ROS compared to 77% of intracellular ROS scavenging effect in N-acetyl-L-cysteine (NAC). Read more...
Cell Research	Rosmarinic acid (RA) is dissolved in DMSO and stored, and then diluted with appropriate media before use. Human keratinocytes (HaCaT cells) are treated with Rosmarinic acid (0.625, 1.25, 2.5, or 5 μM) and exposed to UVB radiation 1 h later. They are then incubated at 37°C for 48 h. At this time, MTT is added to each well to obtain a total reaction volume of 200 μL. After 4 h incubation, the supernatant is removed by aspiration. The formazan crystals in each well are dissolved in dimethyl sulfoxide (DMSO; 150 μL), and the absorbance at 540 nm is measured on a scanning multi-well spectrophotometer. Read more...

Storage & Handling

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Storage	RT
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Apoptosis, COMT, inhibit, IκB, IKK, IKKβ, IkB, IkB/IKK, Monoamine Oxidase, MonoamineOxidase, Inhibitor, Labiatenic acid, MAO, MAO-A, MAO-B, EndogenousMetabolite, Endogenous Metabolite, Rosmarinic acid, Rosemary acid

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Compound Identifiers

PubChem CID

5281792 ↗

Key Properties

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No computed properties available.

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Rosmarinic acid (orb1305049)

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Purity:	98.0%（HPLC）
CAS Number:	20283-92-5

Purity:	99.69%
CAS Number:	537-15-5
MW:	360.31
Formula:	C₁₈H₁₆O₈

CAS Number:	20283-92-5
MW:	360.31
Formula:	C₁₈H₁₆O₈

Purity:	>98% (HPLC)
CAS Number:	20283-92-5
MW:	360.33
Formula:	C₁₈H₁₆O₈

Rosmarinic acid

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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