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Rosuvastatin

SKU: orb1225424

Description

A potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with IC50 of 11 nM; potently inhibits cholesterol biosynthesis (IC50=1.12 nM) in rat isolated hepatocytes, 100 times more potent than pravastatin; also exerts important anti-inflammatory effects via inhibition of endothelial cell adhesion molecule expression.Dyslipidemia Approved(In Vivo):Rosuvastatin Calcium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms.Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins Calcium (VLDL) in diabetes mellitus rats induced by Streptozocin.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number287714-41-4
MW481.5376
Purity>98% (HPLC)
FormulaC22H28FN3O6S
SMILESCC(C)C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C
TargetHMGCR
Solubility10 mM in DMSO

Bioactivity

In Vivo
Rosuvastatin (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms. Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins (VLDL) in diabetes mellitus rats induced by Streptozocin.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ZD-4522

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Rosuvastatin (orb1225424)

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500 mg
5 mg
¥ 1,170.00
10 mg
¥ 1,690.00
25 mg
¥ 2,470.00
50 mg
¥ 3,250.00
100 mg
¥ 5,070.00
200 mg
¥ 6,890.00