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S1R agonist 2

SKU: orb1745159

Description

S1R agonist 2 is a potent and selective sigma-1 receptor agonist, exhibiting high affinity for S1R (Ki = 1.1 nM) over S2R. It demonstrates neuroprotective properties in vitro against oxidative stress and excitotoxicity, making it a valuable research tool for studying neurodegenerative diseases and neuropharmacology.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number150085-21-5
MW309.45
Purity99.66%
FormulaC21H27NO
SMILESC(C1CCN(CCCOC2=CC=CC=C2)CC1)C3=CC=CC=C3
TargetSigma receptor,NMDAR,ROS
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.46 mM);DMSO:50 mg/mL (161.58 mM)

Bioactivity

Target IC50
σ1 receptor:1.1 nM (Ki)|σ2 receptor:88 nM (Ki)
In Vitro
S1R agonist 2 (Compound 8b; 0.1-5 μM) significantly increases neurite growth induced by nerve growth factor (NGF) in a dose-dependent manner and has a neuroprotective effect on NMDA stimulation in SHSY5Y cells. At 1 μM (24 hours), it significantly inhibits cell damage induced by Rotenone in SHSY5Y cells and shows no cytotoxicity to A549, LoVo, and Panc-1 cells (0-10 μM; 24-72 hours).

Storage & Handling

StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ROS, Sigmareceptor, Sigma receptor, NMDA

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Key Properties

No computed properties available.

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S1R agonist 2 (orb1745159)

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% Tween 80 +
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Available Sizes

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2 mg
¥ 1,040.00
5 mg
¥ 1,300.00
10 mg
¥ 1,690.00
25 mg
¥ 2,860.00
50 mg
¥ 4,030.00
100 mg
¥ 5,590.00
200 mg
¥ 7,670.00
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