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Sappanchalcone

SKU: orb1684239

Description

Sappanchalcone

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

Key Properties

CAS Number94344-54-4
MW286.28
Purity98.35%
FormulaC16H14O5
SMILESCOc1cc(O)ccc1C(=O)\C=C\c1ccc(O)c(O)c1
TargetIL Receptor,Bcl-2 Family,TNF,Apoptosis

Bioactivity

In Vitro
The influence o the ethyl acetate (EtOAc) extract of Lignum Sappan and its constituents on growth-related signaling were evaluated by a luciferase assay in cells stably-transfected with NF-κB, STAT1, or STAT3 responsive luciferase Reporter Plasmid the inhibitory effect o the cell cycle was determined by flow cytometric analysis the anti-tumor activities were assessed in vitro and in vivo the EtOAc extract of Lignum Sappan had inhibitory activities on growth-related signaling and cell mitosis. Three major active compounds were Sappanchalcone, brazilin, and butein. Sappanchalcone blocked cell cycle progression in the G2/M phase, brazilin inhibited TNF ± NF-κB signaling, while butein inhibited IL-6/STAT3 signaling, as well as TNF ± NF-κB signaling the three compounds All demonstrated cytotoxic activities against human tumor cells in vitro In a S180 tumor cell-bearing mice model the anti-tumor efficacy o the EtOAc extract was better tha the individual compounds acting alon

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

Sappanchalcone, TNF-α, IL Receptor, ILReceptor, Bcl-2
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Key Properties

No computed properties available.

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Sappanchalcone (orb1684239)

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Available Sizes

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1 mg
¥ 3,770.00
5 mg
¥ 8,970.00
10 mg
¥ 12,090.00
25 mg
¥ 17,810.00
50 mg
¥ 23,790.00
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