Saroglitazar Magnesium

SKU: orb1708589

Description

Saroglitazar Magnesium is a dual PPARα/γ agonist, exhibiting potent PPARα activation (EC50 0.65 pM) and moderate PPARγ activation (EC50 3 nM). This investigational compound is utilized in preclinical research for studying metabolic disorders, including dyslipidemia and fatty liver disease, in both cellular and animal models.

Research Area

Metabolism Research, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	1639792-20-3
MW	901.43
Purity	99.40% (May vary between batches)
Formula	C₅₀H₅₆MgN₂O₈S₂
SMILES	C(C)O1[Mg+2]2(O(CC)C(CC3=CC=C(OCCN4C(=CC=C4C)C5=CC=C(SC)C=C5)C=C3)C(=O)[O-]2)[O-]C(=O)C1CC6=CC=C(OCCN7C(=CC=C7C)C8=CC=C(SC)C=C8)C=C6
Target	Others,PPAR
Solubility	DMSO:112.5 mg/mL (124.8 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (4.44 mM)

Bioactivity

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Target IC50

PPARγ:3 nM （EC50， HepG2 cell）|PPARα:0.65 pM （EC50， HepG2 cell）

In Vivo

In db/db mice, Saroglitazar (0.01-3 mg/kg per day, orally) treatment with 12-day causes dose-dependent reductions in serum triglycerides (TG), free fatty acids (FFA), and glucose. The ED50 for these effects is found to be 0.05, 0.19, and 0.19 mg/kg, respectively with highly significant (91%) reduction in serum insulin and AUC-glucose following oral glucose administration (59%) at 1 mg/kg dose.in Wistar rats and marmosets A 90-day repeated dose comparative study confirms efficacy (TG lowering) potential of Saroglitazar and has indicated low risk of PPAR-associated side effects in humans. Based on efficacy and safety profile, Saroglitazar appears to have good potential as novel therapeutic agent for treatment of dyslipidemia and diabetes.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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PPARγ, PPARα, Saroglitazar Magnesium

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Compound Identifiers

PubChem CID

168012125 ↗

Key Properties

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No computed properties available.

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