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Saroglitazar

SKU: orb1708588

Description

Saroglitazar (Lipaglyn) is a dual PPAR agonist with high potency, exhibiting EC50 values of 0.65 pM for PPARα and 3 nM for PPARγ. It is utilized in research for studying metabolic disorders, including dyslipidemia and type 2 diabetes, in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Molecular Biology

Images & Validation

Key Properties

CAS Number495399-09-2
MW439.57
Purity98.51% (May vary between batches)
FormulaC25H29NO4S
SMILESCCO[C@@H](Cc1ccc(OCCn2c(C)ccc2-c2ccc(SC)cc2)cc1)C(O)=O
TargetPPAR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.55 mM);DMSO:22.5 mg/mL (51.19 mM)

Bioactivity

Target IC50
PPARγ:3 nM (EC50, HepG2 cell)|PPARα:0.65 pM (EC50, HepG2 cell)
In Vivo
In db/db mice, Saroglitazar (0.01-3 mg/kg; orally) reduces serum triglycerides, free fatty acids, and glucose in a dose-dependent manner (ED50 = 0.05, 0.19, and 0.19 mg/kg). Saroglitazar (1 mg/kg) significantly reduces serum insulin and AUC-glucose(91%).

Storage & Handling

Storagekeep away from direct sunlight,store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Lipaglyn, PPARα, PPARγ, Saroglitazar

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

Saroglitazar (orb1708588)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 2,210.00
2 mg
¥ 2,990.00
5 mg
¥ 4,810.00
1 ml x 10 mM (in DMSO)
¥ 5,070.00
10 mg
¥ 7,020.00