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SDZ 224-015

SKU: orb1693647

Description

SDZ 224-015 is a potent, orally bioavailable inhibitor of the IL-1β converting enzyme (caspase-1). It demonstrates anti-inflammatory and anti-COVID-19 activity in research, validated by its efficacy in reducing carrageenan-induced paw edema in rat models and its use in cytokine storm-related in vitro studies.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number161511-45-1
MW652.52
Purity95.49% (May vary between batches)
FormulaC30H35Cl2N3O9
SMILESCCOC(=O)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)COC(=O)c1c(Cl)cccc1Cl
TargetInterleukin,SARS-CoV,IL Receptor,Caspase
Solubility10% DMSO+90% Corn Oil:3.3 mg/mL (5.06 mM);DMSO:80 mg/mL (122.6 mM)

Bioactivity

Target IC50
IL-1β:0.24 µM
In Vivo
SDZ 224-015 (0.3-300 micrograms kg-1) potently reduced carrageenin-induced paw oedema, with an oral ED50 of approximately 25 micrograms kg-1. SDZ 224-015 (0.2-5 mg kg-1, p.o.) displayed analgesic activity in the Randall-Selitto yeast-inflamed paw pressure test, significant at a dose of 1 mg kg-1, p.o.
In Vitro
SDZ 224-015 dose-dependently inhibited the release of IL-1β from the human monocytic cell line THP-1, with an IC50 of 0.24 µM, without affecting the release of IL-6, TNF-α, or lactate dehydrogenase.

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Caspase-1, IL Receptor, ILReceptor, IL-1β converting enzyme, SDZ 224-015, SDZ 224 015, SDZ 224015
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

SDZ 224-015 (orb1693647)

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% DMSO +
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% Tween 80 +
%

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1 mg
¥ 2,470.00
DispatchUsually dispatched within 5-10 working days
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