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SIKs-IN-1

SKU: orb1944454

Description

SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in M1/M2 macrophage polarization linked to inflammation. By inhibiting SIK activity, this compound increases anti-inflammatory cytokine IL-10 and decreases pro-inflammatory cytokine IL-12, demonstrating significant anti-inflammatory efficacy in a DSS-induced colitis model.

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Key Properties

CAS Number2927557-06-8
MW507.58
FormulaC27H31F2N7O
SMILESC(NC1=C(C)C=CC=C1F)(=O)C=2C(NC3CCC3)=NC(NC4=CC(F)=C(C=C4)N5CCN(C)CC5)=NC2
TargetSIK,Others

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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SIKs-IN-1 (orb1944454)

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