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SKF 38393 hydrochloride

SKU: orb1300284

Description

SKF 38393 hydrochloride is a selective agonist for dopamine D1 and D5 receptors. It is widely used in neuroscience research to investigate dopaminergic signaling, including in vitro receptor studies and in vivo models of behaviors such as locomotion and reward.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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SKF 38393 hydrochloride

Key Properties

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CAS Number62717-42-4
MW291.77
Purity98.70% (May vary between batches)
FormulaC16H17NO2·HCl
SMILESCl.Oc1cc2CCNCC(c3ccccc3)c2cc1O
TargetDopamine Receptor
SolubilityEthanol:6 mg/mL (20.56 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:62.5 mg/mL (214.21 mM);10% DMSO+90% Saline:2 mg/mL (6.85 mM)

Bioactivity

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Target IC50
D1:110 nM
In Vivo
SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning.
In Vitro
SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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D5 receptor, D1, Dopamine, Dopamine Receptor, DopamineReceptor, (±)-SKF-38393 hydrochloride, Inhibitor, inhibit, SKF 38393, SKF 38393 Hydrochloride, SKF 38393 hydrochloride, SKF-38393, SKF38393 HCl, SKF38393 Hydrochloride, SKF-38393 Hydrochloride, SKF-38393A, SKF38393

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Quality Guarantee

Quality Guarantee

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Compound Identifiers

PubChem CID
147514 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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25 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 120.00
50 mg
$ 120.00
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