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SKF38393 HCl

SKU: orb1221940

Description

SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.

Images & Validation

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SKF38393 HCl

Key Properties

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CAS Number62717-42-4
MW291.77
Purity>98% (HPLC)
FormulaC16H17NO2·HCl
SMILESCl.OC1=C(O)C=C2C(CNCCC2=C1)C1=CC=CC=C1
TargetAChR
SolubilityDMSO : ≥ 34 mg/mL; 116.53 mM

Bioactivity

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In Vivo
SKF-38393 hydrochloride (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced depletion of glutathione. SKF-38393 hydrochloride attenuates MPTP-induced depletion of dopamine. SKF-38393 hydrochloride enhances the activity of superoxide dismutase and hence mimics the action of Selegiline. SKF-38393 hydrochloride enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action. Animal model: Balb/c mice (20-25 g). Dosage: 5 mg/kg, 10 mg/kg. Administration: Intraperitoneal injection. Result: Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine.
In Vitro
SKF-38393 hydrochloride induces a similar change in cytomorphology and increases the levels of media cAMP. SKF-38393 hydrochloride (10 μmol/L; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells. Western blot analysis. Cell line: GC cells. Concentration: 10 μmol/L. Incubation time: 1 hour. Result: Induced increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells.

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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(±)-SKF-38393 hydrochloride | SKF-38393A

Similar Products

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  • SKF 38393 hydrochloride [orb1300284]

    98.70% (May vary between batches)

    62717-42-4

    291.77

    C16H17NO2·HCl

    25 mg, 50 mg, 1 ml x 10 mM (in DMSO)
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Quick Database Links

Gene Symbol
AChR

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25 mg
$ 100.00
50 mg
$ 130.00
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