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SM-276001

SKU: orb1309085

Description

SM-276001 is a potent and selective Toll-like receptor 7 (TLR7) agonist that acts as an oral interferon inducer. It is utilized in immunological research to study antiviral responses, vaccine adjuvants, and autoimmune disease models in both cellular assays and animal studies.

Research Area

Immunology & Inflammation, Neuroscience

Images & Validation

Key Properties

CAS Number473930-22-2
MW327.38
Purity99.91% (May vary between batches)
FormulaC16H21N7O
SMILESCCCCNc1nc(N)c2[nH]c(=O)n(Cc3ccc(C)nc3)c2n1
TargetIFNAR,TLR,COX
SolubilityDMSO:100 mg/mL (305.46 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.22 mM)

Bioactivity

In Vivo
Oral administration of 0.1 mg/kg SM-276001 in mice shows potent IFN-inducing activity . Twice weekly oral administration of SM-276001 at a dose of 3 mg/kg significantly reduced disease burden in mice bearing either Renca or CT26 tumors..
In Vitro
SM-276001 (1 nM-10 μM) activates NF-κB in a dose-dependent manner via human TLR7 .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, IFN, IFNAR, IFN-α, Interferon-alpha/beta receptor, interferon, Interferon-α/β receptor, inhibit, immune, antitumor, SM 276001, SM276001, SM-276001, Toll-like Receptor (TLR), TLR7
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

SM-276001 (orb1309085)

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Available Sizes

Select a size below

1 mg
¥ 1,300.00
5 mg
¥ 2,470.00
1 ml x 10 mM (in DMSO)
¥ 2,600.00
10 mg
¥ 3,380.00
25 mg
¥ 5,590.00
50 mg
¥ 8,060.00
100 mg
¥ 11,440.00
200 mg
¥ 15,080.00
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