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SSE15206

SKU: orb1220777

Description

SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.

Images & Validation

Key Properties

CAS Number1370046-40-4
MW371.45
Purity>98% (HPLC)
FormulaC19H21N3O3S?
SMILESCOc1cc(cc(OC)c1OC)C1CC(=NN1C(N)=S)c1ccccc1
TargetMicrotubule/Tubulin
SolubilityDMSO:150 mg/mL (403.82 mM)

Bioactivity

In Vitro
SSE15206 induces apoptosis in cells irrespective of MDR-1 overexpression cell lines (KB-V1, A2780-Pac-Res), highly resistant to paclitaxel cells (HCT116-Pac-Res) and parental cells at the concentration of 5 x and 10 x GI50 values. To conclude, SSE15206 is able to overcome resistance to chemotherapeutic drugs such as paclitaxel in different cancer cell lines. Western blot analysis. Cell line: Drug-resistant cell lines (KB-V1, A2780-Pac-Res, HCT116-Pac-Res) and parental cells. Concentration: 5 x and 10 x GI50 values (GI50 = 197 nM in HCT-116 cells). Incubation time: 24 hours. Result: Induced apoptosis in cells irrespective of MDR-1 overexpression and HCT116-Pac-Res and parental cells.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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    1370046-40-4

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SSE15206 (orb1220777)

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Available Sizes

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200 mg
500 mg
2 mg
¥ 1,170.00
5 mg
¥ 1,430.00
10 mg
¥ 1,690.00
25 mg
¥ 2,990.00
50 mg
¥ 4,420.00
100 mg
¥ 6,630.00