SSE15206

SKU: orb1301571

Description

SSE15206 is a small molecule microtubule polymerization inhibitor that disrupts mitotic spindle assembly, leading to G2/M phase arrest. It is a research tool for studying multidrug resistance mechanisms and has demonstrated anti-proliferative effects in both in vitro and in vivo cancer models.

Research Area

Cell Biology, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	1370046-40-4
MW	371.45
Purity	98.81% (May vary between batches)
Formula	C₁₉H₂₁N₃O₃S
SMILES	COc1cc(cc(OC)c1OC)C1CC(=NN1C(N)=S)c1ccccc1
Target	Microtubule Associated,Apoptosis
Solubility	DMSO:150 mg/mL (403.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.77 mM)

Bioactivity

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Target IC50	Microtubule:197 nM (GI50)
In Vitro	Treatment of cells with SSE15206 causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation, a phenotype often associated with drugs that interfere with microtubule dynamics. SSE15206 is able to overcome resistance to chemotherapeutic drugs in different cancer cell lines including multidrug-resistant KB-V1 and A2780-Pac-Res cell lines overexpressing MDR-1, making it a promising hit for the lead optimization studies to target multidrug resistance. Read more...
Cell Research	Fluorescence intensity of tubulin (4 μM) in the presence of colchicine (20 μM) and SSE15206 at indicated concentrations was measured. DMSO was used as a solvent control while 50 μM nocodazole was used as a positive control for colchicine displacement. Samples were incubated for 60 min at 37℃before measurement of fluorescence (excitation at 355 nm and emission at 460 nm). KB-V1 and A2780-Pac-Res cells were incubated with 5 μM rhodamine, for 1 hour at 37℃in the presence or absence of inhibitors. Cells were then washed twice with PBS and incubated in the efflux medium (their respective growth media) in the presence of DMSO, 20 μM verapamil, and 10 μM SSE15206 for 3 hours. The percentage of rhodamine 123 positive cells was determined . Experiments were done in duplicates with 4–5 readings for each sample in each experiment. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, Inhibitor, Microtubule Associated, microtubule, Microtubule/Tubulin, MicrotubuleAssociated, Apoptosis, SSE 15206, SSE15206, SSE-15206

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Compound Identifiers

PubChem CID

56944939 ↗

Key Properties

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No computed properties available.

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SSE15206 (orb1301571)

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Purity:	>98% (HPLC)
CAS Number:	1370046-40-4
MW:	371.45
Formula:	C₁₉H₂₁N₃O₃S?

SSE15206

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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