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Stattic

SKU: orb1300882

Description

Stattic is a selective STAT3 inhibitor (IC50=5.1 µM) that blocks its activation, dimerization, and nuclear translocation. This compound exhibits antitumor and pro-apoptotic activity, making it a valuable research tool for studying STAT3 signaling in cancer models both in vitro and in vivo.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Stattic

Key Properties

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CAS Number19983-44-9
MW211.19
Purity98.54%
FormulaC8H5NO4S
SMILES[O-][N+](=O)C1=CC=C2C=CS(=O)(=O)C2=C1
TargetSTAT,Apoptosis
SolubilityEthanol:1.1 mg/mL (5.21 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1.06 mg/mL (5.02 mM);DMSO:260 mg/mL (1231.12 mM)

Bioactivity

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Target IC50
DU-145 cells proliferation:2.5 μM (48h)|STAT3:5.1 μM (cell free)|A549 cells proliferation:4.4 μM (72h)|A549 cells proliferation:2.5 μM (48h)|ASPC1 cells proliferation:1.32 μM (72h)|HCT116 cells proliferation:1.08 μM (72h)
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In Vivo
METHODS: To test the antitumor activity in vivo, Stattic (10 mg/kg) was administered intraperitoneally once daily for four weeks to BALB/c nude mice harboring human pancreatic adenocarcinoma tumor PANC-1. RESULTS: Stattic inhibited PC growth in a nude mouse tumor model by inactivating STAT3. METHODS: To investigate the role in acute liver injury, Stattic (5 mg/kg in DMSO:olive oil = 1:19) was administered as a single intraperitoneal injection to BALB/c mice with LPS/d-GalN induced acute liver injury. RESULTS: Stattic was protective against LPS/d-GalN-induced liver injury, and its protective effect may be related to its anti-inflammatory and anti-apoptotic effects.
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In Vitro
METHODS: Human pancreatic cancer cells PANC-1 and BxPc-3 were treated with Stattic (1-10 μM) for 12-48 h. Cell viability was measured using the CCK-8. RESULTS: Stattic decreased the proliferation of PANC-1 and BxPc-3 cells in a concentration- and time-dependent manner, and the IC50s of Stattic on BxPc-3 and PANC-1 cells were 3.135-5.296 μM and 3.835-4.165 μM, respectively, after treatment with Stattic for 24 h. METHODS: Human hepatocellular carcinoma cells HepG2 were treated with Stattic (5-20 μM) for 1 h, followed by stimulation with IL-6 or IFN-γ, and the expression levels of target proteins were detected by Western Blot. RESULTS: Pre-incubation with Stattic resulted in a selective decrease in the phosphorylation of STAT3 Tyr705, while the activation of STAT1 Tyr701 remained unchanged.
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Cell Research
MDA-MB-231, MDA-MB-435S, and MDA-MB-453 cells were seeded. at 5 × 10^4 cells in 6-well plates, grown for 24 hr before adding DMSO or Stattic (final DMSO concentration 0.1%) and then incubated with the inhibitor for 24 hr. All cells were collected and resuspended in buffer (0.1% sodium citrate, 0.1% Triton X-100, 20 μM propidium iodide) and incubated for 3 hr before 10^4 cells per sample were analyzed by flow cytometry with a FACSCalibur equipped with a 488 nm laser .
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Storage & Handling

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StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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prostate, Y705, SH2, P-ERK1/2, STAT, STAT3, Stattic, STAT3 Inhibitor V, syndrome, S727, S phase, p-STAT3, Inhibitor, inhibit, PC3M-1E8, cancer, Alport, Apoptosis

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
2779853 ↗

Key Properties

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No computed properties available.

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Stattic (orb1300882)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

5 mg
¥ 910.00
1 ml x 10 mM (in DMSO)
¥ 1,170.00
10 mg
¥ 1,170.00
25 mg
¥ 1,560.00
50 mg
¥ 2,210.00
100 mg
¥ 3,120.00
200 mg
¥ 4,420.00
500 mg
¥ 6,890.00
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