Stattic

SKU: orb1300882

Featured

Description

Stattic is a selective STAT3 inhibitor (IC50=5.1 µM) that blocks its activation, dimerization, and nuclear translocation. This compound exhibits antitumor and pro-apoptotic activity, making it a valuable research tool for studying STAT3 signaling in cancer models both in vitro and in vivo.

Research Area

Cell Biology

Images & Validation

−

Key Properties

−

CAS Number	19983-44-9
MW	211.20
Purity	>98%
Formula	C₈H₅NO₄S
SMILES	[O-][N+](=O)C1=CC=C2C=CS(=O)(=O)C2=C1
Target	Transcription factor
Solubility	Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 1 mg/ml).

Bioactivity

−

Target IC50	DU-145 cells proliferation:2.5 μM (48h)\|STAT3:5.1 μM (cell free)\|A549 cells proliferation:4.4 μM (72h)\|A549 cells proliferation:2.5 μM (48h)\|ASPC1 cells proliferation:1.32 μM (72h)\|HCT116 cells proliferation:1.08 μM (72h) Read more...
In Vivo	METHODS: To test the antitumor activity in vivo, Stattic (10 mg/kg) was administered intraperitoneally once daily for four weeks to BALB/c nude mice harboring human pancreatic adenocarcinoma tumor PANC-1. RESULTS: Stattic inhibited PC growth in a nude mouse tumor model by inactivating STAT3. METHODS: To investigate the role in acute liver injury, Stattic (5 mg/kg in DMSO:olive oil = 1:19) was administered as a single intraperitoneal injection to BALB/c mice with LPS/d-GalN induced acute liver injury. RESULTS: Stattic was protective against LPS/d-GalN-induced liver injury, and its protective effect may be related to its anti-inflammatory and anti-apoptotic effects. Read more...
In Vitro	METHODS: Human pancreatic cancer cells PANC-1 and BxPc-3 were treated with Stattic (1-10 μM) for 12-48 h. Cell viability was measured using the CCK-8. RESULTS: Stattic decreased the proliferation of PANC-1 and BxPc-3 cells in a concentration- and time-dependent manner, and the IC50s of Stattic on BxPc-3 and PANC-1 cells were 3.135-5.296 μM and 3.835-4.165 μM, respectively, after treatment with Stattic for 24 h. METHODS: Human hepatocellular carcinoma cells HepG2 were treated with Stattic (5-20 μM) for 1 h, followed by stimulation with IL-6 or IFN-γ, and the expression levels of target proteins were detected by Western Blot. RESULTS: Pre-incubation with Stattic resulted in a selective decrease in the phosphorylation of STAT3 Tyr705, while the activation of STAT1 Tyr701 remained unchanged. Read more...
Cell Research	MDA-MB-231, MDA-MB-435S, and MDA-MB-453 cells were seeded. at 5 × 10^4 cells in 6-well plates, grown for 24 hr before adding DMSO or Stattic (final DMSO concentration 0.1%) and then incubated with the inhibitor for 24 hr. All cells were collected and resuspended in buffer (0.1% sodium citrate, 0.1% Triton X-100, 20 μM propidium iodide) and incubated for 3 hr before 10^4 cells per sample were analyzed by flow cytometry with a FACSCalibur equipped with a 488 nm laser . Read more...

Storage & Handling

−

Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

prostate, Y705, SH2, P-ERK1/2, STAT, STAT3, Stattic, STAT3 Inhibitor V, syndrome, S727, S phase, p-STAT3, Inhibitor, inhibit, PC3M-1E8, cancer, Alport, Apoptosis

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

2779853 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Stattic (orb1300882)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

MW:	301.36
Formula:	C₁₆H₁₅NO₃S

Purity:	>98% (HPLC)
CAS Number:	19983-44-9
MW:	211.19
Formula:	C₈H₅NO₄S

Stattic

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

STAT3-IN-31 [orb2665593]

Stattic [orb1225759]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Stattic (orb1300882)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors