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Sunvozertinib

SKU: orb1685916

Description

Sunvozertinib

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number2370013-12-8
MW584.08
Purity99.71%
FormulaC29H35ClFN7O3
SMILESCOc1cc(N2CC[C@H](C2)N(C)C)c(NC(=O)C=C)cc1Nc1nccc(Nc2cc(Cl)c(F)cc2C(C)(C)O)n1
TargetBTK,EGFR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (8.56 mM);DMSO:247.5 mg/mL (423.74 mM)

Bioactivity

Target IC50
HER2 exon20 YVMA:7.5 nM|EGFR (L858R/T790M):1.1 nM|EGFR (exon 20 insertion):20.4 nM
In Vivo
METHODS: Blood Samples fro the LU3075 PDX mouse model were collected at 0.5, 1, 2, 4, 8, and 24 hours after administration of sunvozertinib (DZD9008) (12.5, 25, and 50 mg/kg, orally, twice daily) on day 28 for LC/MS-MS analysis. Results Oral sunvozertinib (DZD9008) showed profound anti-tumor efficacy in a dose-dependent manner.
In Vitro
METHODS: To tes the cellular activity of Sunvozertinib (DZD9008) , 14 different EGFRexon20ins were engineered int the Ba/F3 cell line. Results In these cell lines, Sunvozertinib (DZD9008) showed potent pEGFR downregulation activity with IC50 ranging from 6 to 40 nM; in Other cell lines expressing EGFR sensitive mutations, T790M resistance mutations, and rare mutations, Sunvozertinib (DZD9008) downregulated pEGFR more effectively with IC50 ranging from 1.1 to 12 nM; in the A431 cell line overexpressing wild-type EGFR, Sunvozertinib (DZD9008) was less potent in downregulating pEGFR with an IC50 of 58 nM.

Storage & Handling

Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

EGFR, DZD 9008, DZD9008, DZD-9008, BTK, Sunvozertinib

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Key Properties

No computed properties available.

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Sunvozertinib (orb1685916)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 910.00
5 mg
¥ 1,300.00
10 mg
¥ 1,690.00
25 mg
¥ 2,340.00
1 ml x 10 mM (in DMSO)
¥ 2,730.00
50 mg
¥ 3,510.00
100 mg
¥ 5,720.00
500 mg
¥ 19,500.00
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