Survivin Antibody / BIRC5

SKU: orb248127

Description

Survivin, also called BIRC5, is a protein encoded by the human BIRC5 gene. It is a member of the IAP (inhibitor of apoptosis family. Survivin binds to the active form of Caspase-3 and -7, effector or executioner caspases, preventing them from continuing the apoptosis-signaling cascade. Expression is regulated by p53, a regulator of apoptosis-control genes which interacts with the Survivin gene promoter region to repress its expression at the mRNA and protein level.

Images & Validation

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Tested Applications	WB
Dilution Range	Western blot: 2-5ug/ml
Reactivity	Human
Application Notes	Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.

Key Properties

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Antibody Type	Primary Antibody
Host	Rabbit
Clonality	Polyclonal
Isotype	Rabbit IgG
Immunogen	A recombinant protein fragment from human Survivin was used as the immunogen for this antibody.
Purification	Protein A affinity chromatography
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.5 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Western blot testing of human samples with Survivin antibody at 2 ug/ml. Predicted molecular weight ~16 kDa.

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Protocol Information

Western Blot (IB, immunoblot)

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