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Taraxerol

SKU: orb1684967

Description

Taraxerol

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number127-22-0
MW426.72
Purity98.92%
FormulaC30H50O
SMILESCC1(C)CC[C@]2(C)CC=C3[C@]4(C)CC[C@H]5C(C)(C)[C@@H](O)CC[C@]5(C)[C@H]4CC[C@@]3(C)[C@@H]2C1
TargetNF-κB,Apoptosis
SolubilityDMSO:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);THF:5 mg/mL (11.72 mM);Methanol:< 1 mg/mL (insoluble or slightly soluble);H2O:<0.1 mg/ml

Bioactivity

In Vivo
Taraxerol (5 and 10 mg/kg; i.p.) reduces carrageenan-induced paw edema the effect of mg/kg Taraxerol was significant ( < .05) only after 4 hours of carrageenan treatment
In Vitro
Taraxerol (0-100 μM; 24 or 48 hours) significantly reduced cell viability to 95% (20 μM), 89.8% (40 μM), 82.6% (60 μM), 72.9% (80 μM), and 63.6% (100 μM) the cell viability of this compound in HeLa cells at 20 μM and 100 μM concentration within 48 hours was 90.7% and 53.6%, respectively Taraxerol (80 μM; 24 or 48 hours) induces apoptosis and cell death in HeLa cells in a dose-dependent manner. Annexin V/PI double staining method showed that compared to the control group’s apoptotic cell count of 6.5% (early stage) and 0.5% (late stage), Taraxerol significantly induced apoptosis to 24.2% (early stage) and 16.2% (late stage)

Storage & Handling

Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

Alnulin, Apoptosis, NO Synthase, NF-κB, NFκB, NF-kB, NFkB, PGE, TNF-α, Skimmiol, Taraxerol

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Key Properties

No computed properties available.

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Taraxerol (orb1684967)

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1 mg
¥ 1,430.00
5 mg
¥ 2,730.00
10 mg
¥ 4,030.00