Taurochenodeoxycholic acid sodium

SKU: orb1297206

Description

Research Area

Cell Biology, Metabolism Research

Images & Validation

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Key Properties

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CAS Number	6009-98-9
MW	521.68
Purity	99.56%
Formula	C₂₆H₄₄NNaO₆S
SMILES	[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Target	Endogenous Metabolite,Apoptosis
Solubility	10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (3.83 mM);DMSO:262.5 mg/mL (503.18 mM)

Bioactivity

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In Vitro

Experiments were performed with islets from wild-type, farnesoid X receptor (FXR) knockout (KO), and β-cell ATP-dependent K(+) (K(ATP)) channel gene SUR1 (ABCC8) KO mice, respectively Sodium taurochenodeoxycholate (TCDC) increased glucose-induced Insulin secretion. This effect was mimicked b the FXR agonist GW4064 and suppressed b the FXR antagonist guggulsterone. TCDC and GW4064 stimulate the electrical activity of β-cells and enhanced cytosolic Ca(2+) concentration [Ca(2+)](c)). These effects were blunted by guggulsterone. Sodium ursodeoxycholate, which has a much lower affinity to FXR than TCDC, had no effect on [Ca(2+)](c) and Insulin secretion. FXR activation by TCDC is suggested to inhibit K(ATP) current the decline in K(ATP) channel activity by TCDC was only observed in β-cells with intact metabolism and was reversed by guggulsterone. TCDC did not alter Insulin secretion in islets of SUR1-KO or FXR-KO mice. TCDC did not change islet cell apoptosis.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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inhibit, NR8383, JNK, immune, mRNA, Inhibitor, EndogenousMetabolite, Endogenous Metabolite, Calcium Channel, caspase-3, caspase-8, bile, anti-inflammatory, apoptosis, Apoptosis, ATPase, acid, 12-Deoxycholyltaurine, TNF-α, PKC, TIMP-2, Potassium Channel, Taurochenodeoxycholic acid, Taurochenodeoxycholic acid sodium, Sodium taurochenodeoxycholate, regulation

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Compound Identifiers

PubChem CID

23664008 ↗

Key Properties

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No computed properties available.

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