Tebentafusp Antibody

SKU: orb1980600

Description

Tebentafusp (IMCgp100) is a bispecific protein that redirects T-cells to gp100-expressing tumor cells. It has demonstrated anti-tumor activity in clinical research for metastatic uveal melanoma, inducing T-cell activation, cytokine release, and cytotoxicity in both in vitro and in vivo studies.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	1874157-95-5
MW	76.14 kDa
Purity	97.2% (SDS-PAGE); 100% (SEC-HPLC)
Target	TNF,Interleukin

Bioactivity

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In Vivo

In a mouse melanoma model, Tebentafusp administered intravenously at a dose of 10 μg/kg significantly inhibited tumor growth.

In Vitro

Tebentafusp is an ImmTAC that recognizes a peptide derived from the HLA-A*0201-expressed melanoma-specific protein gp100. Tebentafusp was able to stimulate cytotoxic degranulation activity of peripheral blood mononuclear cells (PBMC) against Mel526 cells after 16 hours of treatment at concentrations of 31 pM, 82 pM, and 131 pM, but did not have this effect on gp100-negative A375 cells. When treated at 100 pM for 0-50 h, Tebentafusp was able to mediate the killing of CD8+ T cells, even in the presence of regulatory T cells, and activate caspase 3/7 within 40-48 h. Similarly, when treated at 100 pM for 0-80 h, Tebentafusp was able to trigger the cytotoxic degranulation activity of a subset of CD4+ T cells against melanoma cell cytolysis. At 1, 12, 31, 82 and 131 pM for 24 h or 96 h, Tebentafusp increased granzyme B levels and induced extensive release of cytokines and chemokines from CD4+ and CD8+ T cells.

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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IMCgp100, IMC-gp100, ImmTACgp100, ImmTAC-gp100, TNF Receptor

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Gene Symbol

TNF,Interleukin

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