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Telratolimod

SKU: orb1307684
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Description

Telratolimod (MEDI9197) is a synthetic small molecule agonist of Toll-like receptors 7 and 8 (TLR7/8) developed for oncology research. Its antitumor activity, which involves stimulating innate immune responses, has been investigated in preclinical in vitro and in vivo studies for potential cancer immunotherapy applications.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number1359993-59-1
MW593.89
Purity99.50%
FormulaC36H59N5O2
SMILESCCCCCCCCCCCCCCCCCC(=O)NCCCCOn1c(CCCC)nc2c(N)nc3ccccc3c12
TargetTLR
SolubilityEthanol:12.5 mg/mL (21.05 mM);DMSO:1.8 mg/mL (3.03 mM)

Bioactivity

In Vivo
Telratolimod (50 μg) suppresses the tumor volume and more effectively blocks tumor growth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs the survival of mice bearing large tumors .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Telratolimod, TLR7, TLR8, TLR7/8, TLR, Toll-like Receptor (TLR), MEDI9197, MEDI-9197, MEDI 9197, Inhibitor, inhibit, 3M 052, 3M052, 3M-052

Similar Products

  • Telratolimod [orb1940690]

    >98% (HPLC)

    1359993-59-1

    593.9

    C36H59N5O2

    1 g, 500 mg, 200 mg, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Telratolimod (orb1307684)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 2,860.00
2 mg
¥ 3,770.00
5 mg
¥ 5,460.00
10 mg
¥ 7,800.00
25 mg
¥ 12,220.00
50 mg
¥ 16,380.00
100 mg
¥ 21,970.00
DispatchUsually dispatched within 3-5 working days
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