Teneliximab Antibody

SKU: orb1980613

Description

Teneliximab (BMS 224819) is a chimeric anti-CD40 monoclonal antibody that acts as a partial agonist, blocking CD40-CD40L interactions and depleting peripheral B-cells. It is a research tool for studying autoimmune diseases like rheumatoid arthritis and mechanisms of transplant rejection in both in vitro and in vivo experimental models.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	299423-37-3
MW	146.06 kDa
Purity	95.00%
Target	TNF

Bioactivity

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In Vivo	METHODS: Crab monkey groups were immunized with SRBC and received a single intravenous dose of Teneliximab (BMS 224819) at 10, 40, or 100 mg/kg to observe the ability of Teneliximab (BMS 224819) to inhibit primary Ab responses in vivo. RESULTS Significant inhibition of the primary humoral immune response to SRBC by Teneliximab (BMS 224819) was observed at all three dose levels. Read more...
In Vitro	METHODS: Monocytes were freshly prepared from human blood samples. Cells were cultured with anti-IgM immunoglobulin (5 μg/ml) and Teneliximab (BMS 224819) (5 μg/ml). The effect on cell proliferation was further evaluated. RESULTS Teneliximab (BMS 224819) promoted the proliferation of stimulated B cells. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CD40, Chi220, Anti-Human CD40 Recombinant Antibody, BMS 224819, BMS224819, BMS-224819, Teneliximab

Quality Guarantee

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Gene Symbol

TNF

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