Teneliximab Antibody

SKU: orb1980613

Description

Teneliximab (BMS 224819) is a chimeric monoclonal antibody and a tumor necrosis factor receptor superfamily member 5 (CD40) inhibitor that blocks CD40-CD40L interactions.Teneliximab exerts its partial agonist activity through CD40 and peripheral B-cell depletion, and may be used to study organ transplant rejection and rheumatoid arthritis.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	299423-37-3
MW	146.06 kDa
Purity	95.00%
Target	TNF

Bioactivity

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In Vivo	METHODS: Crab monkey groups were immunized with SRBC and received a Single intravenous dose of Teneliximab (BMS 224819) at 10, 40, or 100 mg/kg to observ the ability of Teneliximab (BMS 224819) to inhibit Primary Ab responses in vivo Results Significant Inhibition o the Primary humoral immune response to SRBC by Teneliximab (BMS 224819) was observed at All three dose levels. Read more...
In Vitro	METHODS: Monocytes were freshly prepared from human blood Samples. Cells were cultured with anti-IgM immunoglobulin (5 μg/ml) and Teneliximab (BMS 224819) (5 μg/ml) the effect on cell proliferation was further evaluated. Results Teneliximab (BMS 224819) promote the proliferation of stimulated B cells. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Disclaimer	For research use only

Alternative Names

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CD40, Chi220, Anti-Human CD40 Recombinant Antibody, BMS 224819, BMS224819, BMS-224819, Teneliximab

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Gene Symbol

TNF

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