TGR5 Receptor Agonist

SKU: orb1307370

Description

This small molecule is a potent and selective agonist of the TGR5 (GPCR19) receptor. It serves as a key research tool for investigating TGR5's role in metabolic regulation, including glucose homeostasis and energy expenditure, in both in vitro assays and in vivo disease models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1197300-24-5
MW	361.22
Purity	99.77%
Formula	C₁₈H₁₄Cl₂N₂O₂
SMILES	CN(C(=O)c1c(C)onc1-c1ccccc1Cl)c1ccc(Cl)cc1
Target	Calcium Channel,GPCR19
Solubility	DMSO:50 mg/mL (138.42 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (27.68 mM);Ethanol:100 mM

Bioactivity

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Target IC50	TGR5/GPCR19 (melanophore cells):7.5(pEC50)\|TGR5/GPCR19 (U2-OS cells):6.8(pEC50)

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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diabetes, CCDC, anti-obesity, Calcium Channel, Ca channels, Ca2+ channels, C57BL/6J mice, bladder hypersensitivity, inhibit, Inhibitor, melanophore cells, G protein-coupled Bile Acid Receptor 1, G-protein coupled receptor 19, GPBAR1, GPCR19, U2-OS cells, TGR5 Receptor Agonist, TGR-5 Receptor Agonist, TGR5 Receptor Agonist, TGR5

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Compound Identifiers

PubChem CID

44605616 ↗

Key Properties

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No computed properties available.

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