Cart summary

You have no items in your shopping cart.

TLR7/8 agonist 7d

SKU: orb1738372

Description

TLR7/8 agonist 1 is a dual agonist of Toll-like receptors 7 and 8, exhibiting immunostimulatory properties. It is utilized in research areas including oncology, antiviral studies, and immune-related diseases, with applications in both in vitro cellular assays and in vivo animal models to investigate innate immune activation.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number1258457-59-8
MW359.47
Purity99.40%
FormulaC22H25N5
SMILESN1=C(N)C=2N=C(N(C2C=3C=CC=CC13)CC4=CC=C(C=C4)CN)CCCC
TargetTLR
SolubilityDMSO:8 mg/mL (22.25 mM)

Bioactivity

Target IC50
TLR7:20 nM (EC50)
In Vitro
TLR7/8 agonist 1 displays significant immunostimulatory activity. The compound can be directly covalently coupled to commercially available fluorescein isothiocyanate (FITC) and rhodamine B isothiocyanate without significant loss of activity. TLR7/8 agonist 1 retains TLR7 agonist activity with an EC50=20 nM.

Storage & Handling

Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CHR-3996, CHR 3996, Nanatinostat, Nanatinostat TFA, Nanatinostat trifluoroacetic acid, Tractinostat, VRx3996, VRx-3996, VRx 3996, TLR7/8 agonist 1, TLR7/TLR8
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

TLR7/8 agonist 7d (orb1738372)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,170.00
5 mg
¥ 2,080.00
10 mg
¥ 2,990.00
25 mg
¥ 5,720.00
50 mg
¥ 9,490.00
100 mg
¥ 15,210.00
DispatchUsually dispatched within 6-8 weeks
Bulk Enquiry