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TNF-α-IN-18

SKU: orb2646152

Description

TNF-α-IN-18 (Compound 61) is a potent TNF-α inhibitor (IC50 = 1.8 µM) that suppresses NF-κB nuclear translocation. It demonstrates low cytotoxicity (CC50 > 50 µM in LM cells) and has shown protective efficacy in murine models of sepsis and rheumatoid arthritis, making it a valuable research tool for inflammation and autoimmune disease studies.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number1272322-42-5
MW336.67
Purity99.77%
FormulaC16H7ClF2O4
SMILESO=C(O)C=1C(=O)C2=CC=C(Cl)C=C2OC1C=3C=C(F)C=CC3F
TargetTNF,NF-κB
SolubilityDMSO:80 mg/mL (237.62 mM)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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TNF-α-IN-18 (orb2646152)

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5 mg
¥ 1,040.00
10 mg
¥ 1,430.00
25 mg
¥ 1,820.00
50 mg
¥ 2,730.00
100 mg
¥ 4,030.00
200 mg
¥ 5,720.00
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