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TNF-α-IN-2

SKU: orb1694041

Description

TNF-α-IN-2 is a potent, orally bioavailable small molecule that disrupts TNFα trimerization and subsequent TNFR1 signaling. It serves as a valuable research tool for investigating TNFα-driven pathologies, including rheumatoid arthritis, in both cellular and animal model studies.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number2074702-04-6
MW494.92
Purity99.92%
FormulaC25H21ClF2N6O
SMILESN([C@H](C)C1=CC(C#N)=CC=C1F)C=2C3=C(C=C(F)C(=N3)C=4C=NC(C(C)(C)O)=NC4)N=C(C)C2Cl
TargetTNF
Solubility10% DMSO+90% Corn Oil:3.3 mg/mL (6.67 mM);DMSO:80 mg/mL (161.64 mM)

Bioactivity

Target IC50
CD40:25 nM
In Vivo
Methods: TNF-α-IN-2 (5-25 mg/kg, oral) was used to treat mice 1 hour before TNF stimulation, an the Changes in IL-6 levels in mice were measured. Results: TNF-α-IN-2 can inhibit TNF-induced IL-6 in mice.
In Vitro
TNF-α-IN-2 can inhibi the expression of E-selectin induced by soluble TNFα in HUVECs cells with an IC50 value of 30 nM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

TNFαIN2, TNF-α-IN-2, TNFα-IN-2, TNF α IN 2, TNF-alpha-IN-2, TNF-a-IN-2
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

TNF-α-IN-2 (orb1694041)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
¥ 4,030.00
5 mg
¥ 8,970.00
10 mg
¥ 13,390.00
25 mg
¥ 26,390.00
50 mg
¥ 41,990.00
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