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TUG-424

SKU: orb1706506

Description

TUG-424 is a potent and selective FFAR1/GPR40 agonist (EC50 = 32 nM) that markedly potentiates glucose-stimulated insulin secretion. This tool compound is valuable for investigating FFAR1's role in pancreatic beta-cell function and metabolic regulation in both in vitro and in vivo research models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1082058-99-8
MW264.32
Purity99.77% (May vary between batches)
FormulaC18H16O2
SMILESCc1ccccc1C#Cc1ccc(CCC(O)=O)cc1
TargetOthers,GPCR
SolubilityDMSO:50 mg/mL (189.16 mM)

Bioactivity

Target IC50
FFA1/GPR40:(EC50)32 nM
In Vitro
At equivalent glucose concentrations, TUG-424's roughly double enhancement of secretion in the context of 12 mM glucose parallels the effect triggered by palmitate. Increasing TUG-424 doses (100 nM to 10 µM) significantly boost glucose-stimulated insulin secretion, beginning notably at 100 nM and peaking at 3 µM. Additionally, TUG-424 slightly yet significantly diminishes basal insulin secretion at 2.8 mM glucose .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

FFA1/GPR40, TUG 424, TUG424, TUG-424
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

TUG-424 (orb1706506)

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Available Sizes

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1 mg
¥ 1,560.00
1 ml x 10 mM (in DMSO)
¥ 2,600.00
5 mg
¥ 2,730.00
10 mg
¥ 3,640.00
25 mg
¥ 5,590.00
50 mg
¥ 8,060.00
100 mg
¥ 11,310.00
500 mg
¥ 22,360.00
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